Markers of Kidney Damage and Nephroprotective Therapy in Radical Cystectomy
Pavlov, V.N.; Pushkarev, A.M.; Kondratenko, Y.V.; Safiullin, R.I.; Alekseev, A.V.
Urologiia 5: 27-30
2015
ISSN/ISBN: 1728-2985 PMID: 26859933 Document Number: 683211
The comparative analysis of changes of the functional (osmolar clearance and fractional excretion of urea) and structural (NGAL, β2-microglobulin in the blood plasma, and NGAL, β2-microglobulin, microalbumin in the urine) biomarkers of kidney damage before and at various stages after radical cystectomy was performed. The study included patients with T2N0M0 stage bladder cancer. The main group consisted of 37 patients receiving nephroprotective treatment (N-acetylcysteine), the comparison group--31 patients receiving background therapy. It was revealed that severity of kidney dysfunction and the incidence of chronic kidney disease in the long-term period after surgery decreased in the main group.