Extracardiac rhabdomyomas--presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling
Iżycka-Świeszewska, E.; Wesołowski, W.; Hermann, B.
Polish Journal of Pathology Official Journal of the Polish Society of Pathologists 66(2): 195-199
2015
ISSN/ISBN: 1233-9687 PMID: 26247533 Document Number: 683184
Extracardiac rhabdomyomas (RM) are very rare benign tumors with a poorly understood pathogenesis. In this report we describe two RM cases--a sublingual adult type tumor and a genital type tumor involving the uterine cervix. The patho-clinical characteristics, as well as the pioneer immunohistochemical analysis of ERK1/2 and AKT/mTOR pathway status is included. The expression of key proteins involved in above signaling gives new insight into the biology of extracardiac RM.