Anticoagulation for continuous renal replacement therapy in the intensive care unit: a comparison of dalteparin infusion with regional citrate anticoagulation
Uljas, E.; Karjalainen, M.; Vaara, S.; Reinikainen, M.
Duodecim; Laaketieteellinen Aikakauskirja 131(11): 1079-1084
2015
ISSN/ISBN: 0012-7183 PMID: 26245070 Document Number: 682604
Continuous renal replacement therapy (CRRT) is used to treat severe acute kidney injury in intensive care units. The aim of this study was to compare two anticoagulation techniques in CRRT, the infusion of dalteparin and regional citrate-calcium anticoagulation, in terms of efficacy and safety. In a retrospective study, we analysed data on 77 dalteparin and 75 citrate-calcium treatment periods. The primary endpoint was the life span of the CRRT circuit. The use of regional anticoagulation with citrate and calcium resulted in a significantly longer CRRT circuit life span as compared to that achieved with dalteparin infusion.