Radiosynthesis and preliminary evaluation of 5- ([11C]methyloxy) -L-tryptophan as PET tumor imaging
He, S.-z.; Wang, S.-x.; Hu, K.-z.; Yao, B.-g.; Tang, G.-h.
Yao Xue Xue Bao 50(5): 565-568
2015
ISSN/ISBN: 0513-4870 PMID: 26234137 Document Number: 682020
The PET tracer 5-([11C]methyloxy)-L-tryptophan (5-(11)CMTP) was prepared by nucleophilic fluorination and alkylation reaction via a two-step procedure in order to develop specific tumor probe. The biodistribution and microPET imaging of 5-(11)CMTP were executed. The results unveiled that the overall radiochemical yield with no decay correction was (14.6 ±7.2) %, the radiochemical purity was more than 95% and high uptake and long retention time of 5-(11)CMTP in liver, kidney and blood were observed but low uptake in brain and muscle were found, furthermore, high uptake of 5-(11)CMTP in tumor tissue was observed. It seems that 5-(11)CMTP will be a potential amino acid tracer for tumors imaging with PET.