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Risk factors for pneumocystis pneumonia in giant cell arteritis: a single-centre cohort study

Berger, C.T.; Greiff, V.; John, S.; Koenig, K.F.; Bigler, M.B.; Recher, M.; Hess, C.; Daikeler, T.

Clinical and Experimental Rheumatology 33(2 Suppl 89: S

2015

ISSN/ISBN: 0392-856X
PMID: 26016762
Document Number: 681656
Pneumocystis jiroveci pneumonia (PCP) is a life-threatening opportunistic infection. Few PCP cases in giant cell arteritis (GCA) have been described, but it remains unknown, which patients need PCP prophylaxis. Sixty-two patients with GCA from a prospective cohort were studied to identify treatment-related predictors of PCP infection. Four PCP infections occurred, all in patients treated with methotrexate in addition to prednisone. Moreover, PCP is associated with higher cumulative PDN doses and severe lymphocytopenia (<400/μl). Our findings support PCP-prophylaxis in GCA patients who are treated with methotrexate and PDN, and need high prednisone doses to achieve remission, or develop severe lymphocytopenia.

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