A Case of Concurrent Cancer of the Esophagus and Stomach with Severe Sepsis following Chemotherapy
Amatatsu, M.; Okumura, H.; Uchikado, Y.; Megumi, K.; Kita, Y.; Uenosono, Y.; Arigami, T.; Mori, S.; Ishigami, S.; Owaki, T.; Natsugoe, S.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 42(10): 1322-1324
2015
ISSN/ISBN: 0385-0684 PMID: 26489586 Document Number: 681651
A 66-year-old man was diagnosed with synchronous early esophageal cancer and advanced gastric cancer. He received CDDP-based combination chemotherapy (docetaxcel, CDDP, and TS-1). During chemotherapy for gastric cancer, he suddenly developed septic shock, requiring intensive treatment with antibiotics, intravenous immunoglobulin, circulatory and respiratory care, and hemoperfusion with a polymyxin B column. He also had disseminated intravascular coagulation (DIC), complicated by sepsis. Recombinant human soluble thrombomodulin (rTM) was administered to treat DIC. The intensive treatments described above allowed the patient to recover from septic shock and DIC several days later. Early and adequate treatment could be used to rescue a compromised cancer-bearing patient from septic shock following chemotherapy.