Collision Lung Cancer Consisting of Squamous Cell Carcinoma and Adenocarcinoma which Showed Identical Epidermal Growth Factor Receptor Mutation;Report of a Case
Motomura, Y.; Mori, T.; Furuhashi, S.; Hayashi, N.; Suzumura, T.; Yamanaka, T.; Sakamoto, O.; Kuriwaki, K.; Kanemitsu, K.; Suzuki, M.
Kyobu Geka. Japanese Journal of Thoracic Surgery 68(9): 793-796
2015
ISSN/ISBN: 0021-5252 PMID: 26329716 Document Number: 680733
We report a 79-year-old woman with collision cancer in the right middle lobe of the lung. She had a persistent abnormal shadow after treatment for pneumonia pointed out in right middle lung field on chest radiogram, and referred to our hospital. On examination, the chest computed tomography showed a pure-solid mass of 7.6 cm in diameter in right middle lobe of the lung which was thought to invade the superior pulmonary vein. She underwent a successful right pneumonecomty, and the postoperative course was uneventful. The tumor proved to be a collision cancer consisting of poor differentiated squamous cell carcinoma and invasive adenocarcinoma, lepidic predominanat by pathological examination. Epidermal growth factor receptor mutations (L858R) were found in both squamous cell carcinoma and adenocarcinoma of the tumor, possibly suggesting the same origin of both histological types.