Research Status on Molecular Basis of Intervertebral Disc Degeneration and Repairing effect of Platelet-Rich Plasma
Gui, K.; Yu, Y.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 29(1): 123-128
2015
ISSN/ISBN: 1002-1892 PMID: 26455186 Document Number: 680361
To review the research status on the molecular basis of intervertebral disc degeneration and the repairing effect of platelet-rich plasma. The related literature about the molecular basis of intervertebral disc degeneration and the repairing effect of platelet-rich plasma was reviewed, analyzed, and summarized. The molecular basis of intervertebral disc degeneration includes genetic influences, cell senescence, decreased matrix production, increased degradative enzyme production, proinflammatory cytokine expression, apoptosis, and neural ingrowth. Platelet-rich plasma can release a series of growth factors to promote intervertebral disc cells proliferation, differentiation, and extracellular matrix synthesis. It can also inhibit proinflammatory effect and apoptosis. Although the prospect of using platelet-rich plasma to repair intervertebral disc degeneration is encouraging, further studies are still needed.