Endocrine disorders and osteoporosis
Kinoshita, Y.
Nihon Rinsho. Japanese Journal of Clinical Medicine 73(10): 1728-1732
2015
ISSN/ISBN: 0047-1852 PMID: 26529938 Document Number: 679956
Secondary osteoporosis is a bone disease characterized by decreased bone mass that predisposes fractures due to underlying disorders or medication. Disorders of the endocrine system, such as primary hyperparathyroidism, hyperthyroidism, hypogonadism, growth hormone deficiency, Cushing's syndrome, and anorexia nervosa frequently cause secondary osteoporosis. In those diseases, hormone excess or deficiency affects functions of osteoblasts, osteocyte, and osteoclasts, leading to aberrant bone remodeling. Bisphosphonates are the first-choice pharmacological agents for fracture prevention in most patients with secondary osteoporosis along with treatment of the underlying disease.