Research Progress of Tissue Engineered Ligament
Sun, Z.; Li, J.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 29(9): 1160-1166
2015
ISSN/ISBN: 1002-1892 PMID: 26750020 Document Number: 679441
To review the research progress of tissue engineered ligament. The literature in recent years on tissue engineered ligament in repair of anterior cruciate ligament (ACL) injury was extensively reviewed, including cell sources, scaffold materials, growth factors, and mechanical stimulation in tissue engineered ligament. Tissue engineered ligament constructed by mesenchymal stem cells and ACL fibroblasts has been successfully used in animal experiments. It is crucial for qualified tissue engineered ligament to choose appropriate seed cells, scaffold, mechanical stimulation, and essential cytokines. To further optimize culture condition and how to realize the tissue engineered ligament in vivo better survival and prognosis need to be further studied. Enormous progress has been made in tissue engineered ligament for repair and regeneration of ACL. With the development of biochemistry and scaffold materials, tissue engineered ligament will be used in clinic in the near future.