Top Abstract Purchase Related
Home
>
Node
>
Subnode

Experimental study of dicholine succinate pharmacokinetics

Kovalev, G.I.; Rychikhin, V.M.; Kudrin, V.C.; Vasil'eva, E.V.; Kondrakhin, E.A.

Eksperimental'naia i Klinicheskaia Farmakologiia 77(11): 23-26

2014

ISSN/ISBN: 0869-2092
PMID: 25668944
Document Number: 677751
We have conducted for the first time an experimental study of pharmacokinetics of dicholine succinate (DCS) for different ways of its administration in rats The quantitative evaluation of DCS and its metabolites was performed by the radioactive isotope technique. Various parameters of DCS pharmacokinetics were estimated, including the dose dependence of drug content in the blood plasma, total bioavailability, distribution kinetics, and the main ways of DCS excretion.

Document emailed within 1 workday
Secure & encrypted payments

Dzheia, P.P.; Toleĭkis, A.I.; Prashkiavichius, A.K. 1980: Effect of experimental myocardial infarct on the succinate oxidation rate and succinate dehydrogenase activity in the heart mitochondria Voprosy Meditsinskoi Khimii 26(5): 591-594
Hankes, G.H.; Lazenby, L.R.; Ravis, W.R.; Belmonte, A.A. 1985: Pharmacokinetics of prednisolone sodium succinate and its metabolites in normovolemic and hypovolemic dogs American Journal of Veterinary Research 46(2): 476-478
Rodionov, A.P.; Ignatova, N.A.; Kushnarev, V.V.; Muzychenko, A.P. 1990: A comparative study of befol pharmacokinetics in experimental animals and man Farmakologiia i Toksikologiia 53(2): 62-63
Karlina, M.V.; Kosman, V.M.; Pozharitskaya, O.N.; Shikov, A.N.; Makarov, V.G. 2016: Experimental Study of Pharmacokinetics of Ketoprofen Nanosystem for Inhalation Administration Eksperimental'naia i Klinicheskaia Farmakologiia 79(7): 21-24
Ortenberg, Z.A. 1978: Pharmacokinetics of isoniazid, PAS, and cycloserin in acute and chronic alcoholic intoxication (experimental study) Problemy Tuberkuleza 9: 60-64
Hörnchen, U.; Schüttler, J.; Stoeckel, H.; Eichelkraut, W. 1988: Pharmacokinetics and dynamics of endogenously released and therapeutically administered adrenaline in resuscitation. A comparative animal experimental study Der Anaesthesist 37(10): 615-619
Kochetygov, N.I.; Panysheva, T.I.; Remizova, M.I. 1984: Effect of sodium succinate on the restoration of the functional activity of mitochondria in experimental burn shock Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1: 33-35
Westhovens, Ré.; Houssiau, Fédéric.; Joly, J.; Everitt, D.E.; Zhu, Y.; Sisco, D.; Van Hartingsveldt, B.; Mascelli, M.Ann.; Graham, M.A.; Durez, P.; Bouman-Thio, E. 2006: A phase I study assessing the safety, clinical response, and pharmacokinetics of an experimental infliximab formulation for subcutaneous or intramuscular administration in patients with rheumatoid arthritis Journal of Rheumatology 33(5): 847-853
Liul'ka, A.N.; Koval'chuk, L.A. 1976: Histochemical characteristics of the activity of succinate dehydrogenase and cytochrome oxidase in certain tissues and organs of patients with thyrotoxicosis and animals with experimental thyroidin toxicosis Problemy Endokrinologii 22(6): 101-106
Beznosko, B.K.; Dobrina, V.A.; Ioffe, D.V.; Kolganova, O.I.; Lukomskaia, N.I. 1980: Importance of the components of the complex ester group for the action of acetylcholine and dicarboxylic acid dicholine esters Farmakologiia i Toksikologiia 43(1): 44-48
Toledano, A.; Martinez, R. 1970: Histochemical and biochemical study of the cerebellum of the cat. II. Cytochrome oxidase and succinate dehydrogenase activities Annales d'Histochimie 15(3): 219-229
Kikuchi, Y. 1994: Study of in vitro cancer sensitivity of anticancer drugs by Sdi (succinate dehydrogenase inhibition test) Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(16): 2757-2762
Pang, Y.N.; Zhang, Z.R.; Pang, Q.J.; Li, T.L. 2001: Study on the enzyme dependant colon targeting prodrug--dexamethasone succinate dextran and its tablets Yao Xue Xue Bao 36(8): 625-630
Koroleva, V.G.; Fomina, I.P. 1976: Pharmacokinetics of lincomycin in experimental animals Antibiotiki 21(12): 1090-1094
Cao, X.-p.; Wang, S.-b.; Zhou, H.; Wu, H.-y.; Zhang, Y.-x.; Liu, X.-j.; Zhang, S.-t. 2008: The study of apoptosis induction effect of vitamin e succinate on Tca8113 human tongue cancer cells Hua Xi Kou Qiang Yi Xue Za Zhi 26(4): 362-364
Fateeva, L.I.; Poliak, M.S. 1977: Pharmacokinetics of lincomycins in experimental staphylococcal sepsis Antibiotiki 22(7): 624-629
Sokolov, V.V.; Nartsissov, R.P.; Ivanova, L.A. 1970: Analysis of the lymphocyte population in the cytochemical study of alpha-glycerophosphate and succinate dehydrogenase in patients with occupational diseases Problemy Gematologii i Perelivaniia Krovi 15(8): 22-25
Benassai, C.; Fontanari, P.; Messori, A.; Valenza, T.; Fabbri, L.P.; Linden, M.; Nucera, M.; Boncinelli, S. 1990: Pharmacokinetics of propofol in experimental orthotopic transplant of the liver Minerva Anestesiologica 56(9): 765-768
Verma, P.S.; Adir, J.; Miller, R.L. 1990: Effect of experimental hyperthyroidism on atropine pharmacokinetics in sheep Methods and Findings in Experimental and Clinical Pharmacology 12(2): 115-118
Fujita, H.; Okamoto, M.; Takao, A.; Mase, H.; Kojima, H. 1994: Pharmacokinetics of paclitaxel in experimental animals. Part 2. Tissue distribution Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(5): 659-664