Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine
Mittal, S.R.
Journal of the Association of Physicians of India 62(5): 426-427
2014
ISSN/ISBN: 0004-5772 PMID: 25438492 Document Number: 677603
A case of unstable angina developed slow junctional rhythm with QTc prolongation and transient Torsades de pointes following simultaneous use of Ivabradine, Diltiazem and Ranolazine. Effect of Diltiazem on hepatic isoenzyme CYP 3A could be responsible. Such a combination should be avoided.
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