Intra-tumoral hemorrhage of a relapsed CNS diffuse large B-cell lymphoma: a case report
Kim, T-Kyun.; Wajima, D.; Yonezawa, T.; Takamura, Y.; Miyamae, S.
No Shinkei Geka. Neurological Surgery 42(7): 651-658
2014
ISSN/ISBN: 0301-2603 PMID: 25006106 Document Number: 677367
We report a case of a relapsed central nervous system(CNS)lymphoma with an intra-tumoral hemorrhage. A 75-year-old man was transferred to our hospital because of sensory aphasia. He was diagnosed with a left temporoparietal brain tumor having intra-tumoral hemorrhage. Emergency resection of the tumor was performed. The pathological diagnosis was diffuse large B-cell lymphoma(DLBCL). Chemotherapy and radiation therapy were performed, and the patient achieved remission. Isolated relapsed CNS DLBCL accompanied by an intra-tumoral hemorrhage has been very rarely reported. Immunohistochemistry findings showed increased expression of vascular endothelial growth factor(VEGF)in the cytoplasm of tumor cells. This may correlate to the intra-tumoral hemorrhage, as indicated by previous reports.