Psychopharmacological treatment of delirium: does earlier treatment and scheduled dosing improve outcomes?
Weiss, A.; Scheeringa, M.S.
Journal of the Louisiana State Medical Society Official Organ of the Louisiana State Medical Society 166(6): 242-247
2014
ISSN/ISBN: 0024-6921 PMID: 25978660 Document Number: 677349
The goals of this study were to examine how dosing strategies and timeliness of antipsychotic medication initiation would affect delirium duration. This is a retrospective paper and electronic record review of patients in an academic hospital who had been diagnosed with delirium. Forty-two patients met inclusion criteria. Quantitative and qualitative data on the course of delirium was gathered, as well as important demographic and medical variables. There were no significant differences in duration of delirium between the scheduled and PRN groups using survival analysis, although the test was marginally significant (log rank test, p<0.06). Those who received treatment within 24 hours of recognition had significantly shorter durations of delirium compared to those who began treatment after 24 hours (log rank test, p<0.006). These data suggest that early psychopharmacological treatment of delirium can reduce duration. Future research needs to investigate prompt and scheduled medication dosing strategies for treatment of delirium symptoms.