Possible mechanisms of Roux-en-Y gastric bypass treatment for type 2 diabetes mellitus
Dong, G.; Xu, X.
Zhonghua Wei Chang Wai Ke Za Zhi 17(7): 737-740
2014
ISSN/ISBN: 1671-0274 PMID: 25070458 Document Number: 676894
Roux-en-Y gastric bypass(RYGB) is a classic procedure for the treatment of type 2 diabetes mellitus (T2DM), but it remains unclear why this procedure works. There might be several mechanisms that RYGB works through to treat T2DM, including calorie restriction and malabsorption, improvement of insulin resistance and β-cell functions, and altered secretion of gastrointestinal hormones. Altered levels of adipokines and serum bile acids might also play a role after RYGB. Future researches should concentrate on the exact mechanism of the altered hormone levels after RYGB, and whether different methods of gastrointestinal tract reconstruction could lead to various hormone levels.