Excerpts from the clinical-pharmacologic and clinical studies of Grandaxin
Szegó, J.; Somogyi, M.; Papp, E.
Acta Pharmaceutica Hungarica 63(2): 91-98
1993
ISSN/ISBN: 0001-6659 PMID: 8100114 Document Number: 6768
The authors give a selection from the clinical-pharmacological and clinical studies of Grandaxin (tofizopam), an original Hungarian compound registered in 1976. Tofizopam, a 2,3-benzodiazepine derivative, differs from "classical" 1,4-benzodiazepines not only in chemical structure, but also in pharmacological and clinical-pharmacological properties. It is an anxiolytic without sedative-hypnotic, muscle relaxant and anticonvulsive effects. Tofizopam does not impair psychomotor and intellectual performance, like other benzodiazepines do, in the contrary, it has a mild stimulatory activity. It is potent in alleviating vegetative symptoms accompanying anxiety disorders. Tofizopam has a very low toxicity, mild side effects. The administration of tofizopam does not lead to physical or psychic dependence.
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