Simultaneous treatment of HIV and tuberculosis is possible and necessary

Von der Maase, S.; Gerstoft, J.; Wejse, C.; Von der Maase, S; Gerstoft, J; Wejse, C

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Simultaneous treatment of HIV and tuberculosis is possible and necessary

Von der Maase, S.; Gerstoft, J.; Wejse, C.

Ugeskrift for Laeger 176(6a): V03130163

2014

ISSN/ISBN: 1603-6824

PMID: 25347439

Document Number: 676777

The proper timing of antiretroviral therapy (ART) to HIV-patients co-infected with tuberculosis has been debated. We review three studies on this matter. One study found a significant reduced mortality for patients with CD4+ T-cell counts (CD4+) ≤ 200 per mm3 who received ART early, whereas the other two studies found this difference for patients with CD4+ < 50 per mm3.The risk of immune reconstitution inflammatory syndrome was significantly increased for the patients receiving ART early, but this contributed only to a small fraction of deaths related to HIV after the initiation of ART.