Current possibilities of correcting subchondral bone resorption as a major pathogenetic factor for progressive osteoarthrosis
Naumov, A.V.
Terapevticheskii Arkhiv 86(1): 60-65
2014
ISSN/ISBN: 0040-3660 PMID: 24754071 Document Number: 676612
The paper considers the current pathogenesis, by choosing the actual targets of pharmacotherapy with available drugs. It reflects the cytokine mechanisms responsible for lesion of the synovial membranes, cartilage, and subchondral bone. Particular emphasis is laid on the role of chondroitin sulfate, glucosamine, vitamin D3 as drugs that affect the key components of pathogenesis, including the volume of resorptive cavities in the subchondral bone.