Specific features in pharmacokinetics of the original neuroleptic dilept in animals and humans
Shevchenko, R.V.; Litvin, A.A.; Kolyvanov, G.B.; Boĭko, S.S.; Zherdev, V.P.
Eksperimental'naia i Klinicheskaia Farmakologiia 77(7): 23-26
2014
ISSN/ISBN: 0869-2092 PMID: 25322650 Document Number: 675941
Interspecies differences in pharmacokinetics of the original neuroleptic drug dilept have been studied in experimental animals (rabbits and rats) and volunteers after single oral administration of tablets and tablet mass of the drug. Parent drug in the rabbit blood plasma was detected for 4 h, in the rat plasma for about 2 h, and in the human blood plasma for about 1 h after drug administration. The degrees of dilept biotransformation into metabolites (defined as metabolism intensity, AUCM/AUCP) in rats were 21.3 (for M-1) and 1645 (for M-2), in human volunteers - 5.8 and 658.5, and in rabbits - 1.6 and 125.8, respectively. Thus, the intensity of drug metabolism in experimental animals and volunteers was different and decreased in the series rats humans rabbits.