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Advances in the application of gene therapy for Parkinson's disease with adeno-associated virus

Chen, Y.; Lü, Y.-H.; Li, Z.-F.

Yao Xue Xue Bao 49(5): 576-581

2014

ISSN/ISBN: 0513-4870
PMID: 25151724
Document Number: 675276
Vectors used to carry foreign genes play an important role in gene therapy, among which, the adeno-associated virus (AAV) has many advantages, such as nonpathogenicity, low immunogenicity, stable and long-term expression and multiple-tissue-type infection, etc. These advantages have made AAV one of the most potential vectors in gene therapy, and widely used in many clinical researches, for example, Parkinson's disease. This paper introduces the biological characteristics of AAV and the latest research progress of AAV carrying neurotrophic factor, dopamine synthesis related enzymes and glutamic acid decarboxylase gene in the gene therapy of Parkinson's disease.

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Ohi, S. 2000: Developing protocols for recombinant adeno-associated virus-mediated gene therapy in space Journal of Gravitational Physiology: a Journal of the International Society for Gravitational Physiology 7(2): P67-P68
Małecki, M.; Swoboda, P.ł; Pachecka, J. 2009: Recombinant adeno-associated virus derived vectors (rAAV2) efficiently transduce ovarian and hepatocellular carcinoma cells--implications for cancer gene therapy Acta Poloniae Pharmaceutica 66(1): 93-99
Beutler, A.S.; Banck, M.S.; Walsh, C.E.; Milligan, E.D. 2005: Intrathecal gene transfer by adeno-associated virus for pain Current Opinion in Molecular Therapeutics 7(5): 431-439
Arai, Y.; Kubo, T.; Fushiki, S.; Mazda, O.; Nakai, H.; Iwaki, Y.; Imanishi, J.; Hirasawa, Y. 2000: Gene delivery to human chondrocytes by an adeno associated virus vector Journal of Rheumatology 27(4): 979-982
Zhou, S.Z.; Broxmeyer, H.E.; Cooper, S.; Harrington, M.A.; Srivastava, A. 1993: Adeno-associated virus 2-mediated gene transfer in murine hematopoietic progenitor cells Experimental Hematology 21(7): 928-933
Gnatenko, D.; Arnold, T.E.; Zolotukhin, S.; Nuovo, G.J.; Muzyczka, N.; Bahou, W.F. 1997: Characterization of recombinant adeno-associated virus-2 as a vehicle for gene delivery and expression into vascular cells Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research 45(2): 87-98
Qiu, G.; Wang, S.; Wang, S.; Shao, Q.; Ma, J.; Yang, M.; Xu, X.; Mao, C.; Su, Z.; Huang, X.; Xu, H. 2009: Adeno-associated virus mediated T-bet gene transfer into SGC-7901 cell to regulate IFN-gamma production Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26(3): 606-609; 619
Wang, G.; Yu, C.-J.; Dong, X.-Y.; Tian, W.-H.; Wu, X.-B. 2012: Recombinant adeno-associated virus type 8 mediated dual-luciferase gene expression in mouse Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 26(6): 439-441
Fan, D.; Shen, Y.; Kang, D.; Nakano, I.; Ozawa, K. 2001: Adeno-associated virus vector-mediated triple gene transfer of dopamine synthetic enzymes Chinese Medical Journal 114(12): 1276-1279
Koppold, B.; Sauer, G.; Büning, H.; Hallek, M.; Kreienberg, R.; Deissler, H.; Kurzeder, C. 2005: Efficient gene transfer of CD40 ligand into ovarian carcinoma cells with a recombinant adeno-associated virus vector International Journal of Oncology 26(1): 95-101
Li, J.; Chen, G.; Gao, Q.-l.; Xing, H.; Wu, S.-f.; Zhang, A.-l.; Wang, S.-x.; Lu, Y.-p.; Ma, D. 2003: Reversion of ovarian carcinoma metastasis by adeno-associated virus-mediated gene transfer of nm23H1 in orthotopic implantation model Zhonghua Yi Xue Za Zhi 83(19): 1671-1675
Li, H.-H.; Zhang, S.-M.; Fang, S.-Y.; Chen, C.-L.; Luo, Y.-D.; Guan, Y.; Wang, D.-W.; Xiao, X. 2003: Adeno-associated virus vector carrying human minidystrophin gene SMCKA3999 effectively ameliorates dystrophic pathology in mdx model mice Zhonghua Yi Xue Za Zhi 83(17): 1513-1516
Sun, J.-h.; Ma, Y.-l.; Peng, M.-e.; Bie, A.-g.; Li, L.; Liu, L. 2010: Killing effect of dendritic cell vaccine transfected by recombinant adeno-associated virus with hAFP gene fragment on hepatocellular carcinoma cells in vitro Zhonghua Zhong Liu Za Zhi 32(5): 334-338
Qi, X.-J.; Wang, S. 2011: Effects of penetration therapy with scalp electroacupuncture on gene expressions of nerve growth factors in substantia nigra of rats with Parkinson's disease Zhongguo Zhen Jiu 31(5): 435-440
Lombardo, L. 1974: Recent advances in the therapy of Parkinson's syndrome Gaceta Medica de Mexico 107(6): 513-524
Martocci, R.J. 1975: Recent advances in the treatment of Parkinson's disease Journal of the American Osteopathic Association 74(8): 730-741
Friedman, J. 1986: Recent research advances in Parkinson's disease: Part I Rhode Island Medical Journal 69(7): 319-322
Chen, X.; Gumina, G.; Virga, K.G. 2019: Recent Advances in Drug Repurposing for Parkinson's Disease Current Medicinal Chemistry 26(28): 5340-5362
Nau, J.-Y. 2014: Parkinson: the latest results of gene therapy Revue Medicale Suisse 10(414): 202-203
Friedman, J. 1986: Recent research advances in Parkinson's disease: Part II. Studies in lower animals indicate a future for brain implants Rhode Island Medical Journal 69(8): 361-363