Lung recruitment strategies and surfactant in neonatal intensive care unit
Vento, G.; Tana, M.; Tirone, C.; Aurilia, C.; Lio, A.; Ricci, C.; Gambacorta, A.; Romagnoli, C.
Acta Bio-Medica Atenei Parmensis 85(1): 11-14
2014
ISSN/ISBN: 0392-4203 PMID: 24957340 Document Number: 674883
Several studies in the lamb model have shown that hyperinflation of the lungs early in life may cause a blunted response to surfactant with signs of lung injury and any attempt to recruit lung volume in the surfactant deficient preterm infant by large lung inflations at birth should be potentially dangerous. As regards the situation when surfactant is given later, as rescue treatment for established RDS, the evidence for a clinically beneficial effect of a recruitment maneuver is yet insufficient and, hopefully, future studies will gather more data on this aspect.