Evaluation of primary prophylaxis with granulocyte colony-stimulating factor for epithelial ovarian cancer
Matsui, K.; Mori, T.; Sawada, M.; Kuroboshi, H.; Tatsumi, H.; Yoshioka, T.; Akiyama, M.; Yamamoto, T.; Iwasaku, K.; Kitawaki, J.
European Journal of Gynaecological Oncology 35(1): 48-51
2014
ISSN/ISBN: 0392-2936 PMID: 24654461 Document Number: 674843
Primary prophylaxis with G-CSF has been used to minimize myelosuppression caused by anticancer agents and to avoid severe neutropenia. The authors retrospectively examined the value of primary prophylaxis using granulocyte colony-stimulating factor (G-CSF) for epithelial ovarian cancer. From 2001 to 2010, 105 patients with ovarian cancer receiving chemotherapy in the present hospital were divided into two groups: one received primary prophylaxis with G-CSF and the other did not receive it in compliance with the guidelines for G-CSF usage. The incidence of febrile neutropenia (FN), degree of neutropenia, frequency of G-CSF administration, number of days of hospitalization, progression-free survival (PFS), and overall survival (OS) were evaluated. Neutrophils decreased almost equally and the length of hospitalization was not significantly lower between the groups. Five-year PFS or OS showed no significant difference either. Primary prophylaxis with G-CSF in chemotherapy for epithelial ovarian cancer could be of low significance.