Effective chemotherapy with bevacizumab/FOLFOX4 for neuroendocrine carcinoma of the ascending colon - a case study
Tanabe, H.; Takase, T.; Morimoto, D.; Tanaka, Y.; Shibata, A.; Yaguchi, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 41(5): 661-664
2014
ISSN/ISBN: 0385-0684 PMID: 24917018 Document Number: 674725
A 63-year-old woman underwent surgery for Stage IV cancer of the ascending colon with multiple lymph node metastases. The pathological diagnosis was neuroendocrine carcinoma. Following first-line chemotherapy, the patient presented clinically with progressive disease (PD). Second-line chemotherapy with bevacizumab/Leucovorin and 5-fluorouracil with oxaliplatin (FOLFOX4) was effective and a partial response (PR) was achieved after 7 courses of therapy, as determined by computed tomography (CT) examination. Neuroendocrine carcinoma is known to be extremely malignant; however, this case suggests that chemotherapy with bevacizumab may improve the prognosis of this disease.