MicroRNA and left ventricular hypertrophy
Duan, L.; Xiong, X.-j.; Liu, Y.-m.; Wang, J.
Zhongguo Zhong Yao Za Zhi 39(17): 3211-3215
2014
ISSN/ISBN: 1001-5302 PMID: 25522599 Document Number: 674688
MicroRNAs (miRNA) plays an important role in biological development and disease occurrence and development, and acts as a "main switch" in biology. Among patients of essential hypertension, around 1/3 would suffer left ventricular hypertrophy (LVH). Hence, essential hypertension becomes an independent risk factor for cardiovascular diseases. And miRNAs plays an important role in the occurrence and development of LVH. This paper reviewed the role of miRNA in regulating the stress signaling pathway, defined its impact on the occurrence of LVH, and further emphasized the opportunities and challenges of miRNA as a biomarker and therapeutic target.