Clinical pathogenetic role of neurohumoral regulation in the build up of vegetative dysfunction in patients with purulent meningitis
Georgian medical news 2014(234): 79-84
2014
ISSN/ISBN: 1512-0112 PMID: 25341244 Document Number: 674571
The article presents information obtained during the examination of 60 patients with purulent meningitis. It is shown that in patients with purulent meningitis in the acute period of the disease objective clinical signs of autonomic dysfunction detected only 23.3% of the predominance general intoxication and cerebral syndromes, accompanied by a decrease in the power spectra of all studied heart rate variability in the presence of autonomic dysfunction aside vagotonia in together with elevated levels of adrenocorticotropic hormone and low serum growth hormone levels. Starting from the 2 week of illness clinical signs of autonomic dysfunction detected in 95.0% of patients with purulent meningitis of recourse against the backdrop general intoxication manifestations and cerebral syndromes and combined with a progressive decrease in the power spectrum of humoral influences and quantitative content of growth hormone in the blood serum. In the recovery period of purulent meningitis in most patients (72.7%) persistence of symptoms of autonomic dysfunction is combined with low power core spectra of heart rate variability, parasimpatikotonia and endocrine imbalance.