The influence of depression on the course of coronary heart disease and quality of life
Garganeeva, N.P.; Petrova, M.M.; Evsyukov, A.A.; Shtarik, S.Y.; Kaskaeva, D.S.
Klinicheskaia Meditsina 92(12): 30-37
2014
ISSN/ISBN: 0023-2149 PMID: 25980296 Document Number: 674367
We undertook the analysis of cardiovascular risk factors and psycho-social factors in 230 patients with coronary heart disease (CHD) based at a city polyclinic. Ninety (31.1%) patients suffered depression (19-28 CES-D scores). Patients with and without depression were significantly different in terms of clinical and functional manifestations of stable angina of effort, cardiovascular risk factors, gender; and psycho-social factors. CHD with depression was associated with a higher FC of angina of effort, risk of adverse outcome (Duke index), frequency of concomitant pathology, psycho-social stress, loss of working capacity and a lower income levels. These patients treated with selective antidepressants (serotonin reuptake inhibitors) for 6 months experienced a marked decrease in the degree of depression and manifestation of its symptoms, improvedpsycho- social protection and quality of life compared with untreated patients. These data illustrate pathogenetic and behavioural mechanisms underlying the relationship between CHD and depression.