Gorlin-Goltz syndrome and stroke: a case report
Budinčević, H.; Starčević, K.; Bielen, I.; Demarin, V.
Acta Dermatovenerologica Croatica Adc 22(3): 209-212
2014
ISSN/ISBN: 1330-027X PMID: 25230063 Document Number: 674172
We report on the case of a 32-years old male patient who was previously diagnosed with Gorlin-Goltz syndrome. The patient presented with sudden-onset right-sided hemiparesis, supranuclear facioparesis, and motor aphasia. He was treated with thrombolytic therapy, which successfully alleviated the symptoms. Subsequent radiologic work-up revealed anomalies in the vertebral arteries, a bifid rib, an ischemic lesion in the supply area of the left middle cerebral artery, and falx calcifications. Laboratory tests showed a 4G/4G polymorphism of the plasminogen activator inhibitor 1 (PAI-1) gene whose correlation with stroke is discussed in the article.