Contemporary possibilities of non-oral estrogen-progestin contraception
Driák, D.
Casopis Lekaru Ceskych 153(3): 142-145
2014
ISSN/ISBN: 0008-7335 PMID: 24968292 Document Number: 673505
Besides the classic combined oral contraception (pill), there are alternative medical forms as transdermal contraception system, vaginal ring, intramuscular injections, and percutaneous gel, respectively. The mechanism of contraceptive effect is the same as well as they are the contraindications. The advantage of non-oral application is the elimination of the first-pass effect that enables reduction of doses, diminishing of undesirable side-effects and medical interactions, and only small effect on enzymatic systems associated with cytochrome P450. As the main advantage, comfort and better compliance of patients who have problems with daily use of tablets, is considered.