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Laboratory-Based Clinical Research i am Aiming for

Yatomi, Y.

Rinsho Byori. Japanese Journal of Clinical Pathology 62(11): 1052-1055

2014

ISSN/ISBN: 0047-1860
PMID: 27509720
Document Number: 672240
We have pursued the clinical introduction of assays of lysophospholipids and related proteins. One such example is the multi-functional lysophospholipid mediator lysophosphatidic acid (LPA), which is produced from lysophosphatidylcholine (LPC) through the lysophospholipase D (lysoPLD) activity of autotaxin (ATX) in body fluids. Determination of the LPA concentration in body fluids, especially plasma, is clinically relevant and important for diagnostic purposes, and we have succeeded in the elucidation of disease states in which the levels of LPA/ATX are altered; ATX is promising as a biomarker for several diseases. The department of clinical laboratory in the hospital is a suitable section to perform such research, for which sophisticated assays and sampling techniques are needed.

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