Disorders of gut microflora in the pathogenesis of liver cirrhosis and complications of portal hypertension
Anikina, E.V.; Kovtun, A.V.; Iakovenko, A.V.; Gioeva, I.Z.; Iakovenko, É P.; Agafonova, N.A.; Ivanov, A.N.; Volosheĭnikova, T.V.; Grigor'eva, I.V.
Eksperimental'naia i Klinicheskaia Gastroenterologiia 12: 20-23
2014
ISSN/ISBN: 1682-8658 PMID: 26058107 Document Number: 672135
A total of 85 patients with alcoholic and viral cirrhosis were included in study to assess the prevalence of dysbiosis and its relationship with the severity of disease, and with development of dyspeptic disorders. Intestinal bacterial over-growth was measured by means of a lactulose breath test, fecal flora was cultured under aerobic and anaerobic conditions. Intestinal bacterial overgrowth and colon dysbiosis were determined in 82.4% of patients with equal prevalence in alcoholic and viral cirrhosis. Intestinal dysbiosis was found to be risk factor of increasing cirrhosis severity and liver dysfunction, as well as development of complications of portal hypertension. It was documented, that intestinal dyspepsia syndrome in cirrhotic patients is strongly associated with the presence of gut microflora disorders.