Current status of urinary cytology in the evaluation of bladder neoplasms
Ondič, O.; Slunéčko, R.; Svajdler Ml, Mán.
Ceskoslovenska Patologie 50(4): 142-145
2014
ISSN/ISBN: 1210-7875 PMID: 25418901 Document Number: 672003
Urine cytology is a reliable method for identification and follow up of the patients who develop high-grade urothelial carcinoma. Reactive changes of superficial and intermediate urothelial cells cytologically often mimic low grade urothelial carcinoma. This is the cause of relatively high number of false positive and false negative results. Diagnostic accuracy can be improved introducing different procedures for material handling namely cytospin and liquid based cytology and new diagnostic protocols such as FISH for chromosomal aberrations or mRNA and miRNA analysis. Most recently Next Generation Sequencing for DNA analysis was applied. Availability of clinical information improves the diagnostic accuracy and shortens the time to diagnosis.