Risk of manifestation of endogenous psychosis in patients with nonpsychotic mental disorders of juvenile age
Omel'chenko, M.A.; Golubev, S.A.; Nikiforova, I.I.; Kaleda, V.G.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 114(6): 14-20
2014
ISSN/ISBN: 1997-7298 PMID: 25042485 Document Number: 671999
To identify people at high risk of endogenous psychosis in patients of juvenile age with nonpsychotic mental disorders. Authors examine 49 patients of juvenile age with symptoms of nonpsychotic mental disorders (ICD-10 diagnoses of mood disorder, personality disorder or schizotypal disorder). In all cases, symptoms related to signs of the premorbid stage of endogenous psychosis (schizophrenia and schizoaffective psychosis) were identified. After psychopharmacological treatment, an incomplete (<30%) reduction of psychopathological disorders recorded at admission was found in 24.5% of patients. Based on the response of patients to treatment, family history (having a first-degree relative with psychosis) and the diagnosis of mental disorder, it was singled out "high-risk" (20.4% patients) and "ultra-high risk" (18.4%) states for psychosis. In light of these findings, the necessity of a longitude prospective study of these patients and pharmacological interventions in outpatient conditions is discussed.