Change in the blood cytokine spectrum in patients with pulmonary sarcoidosis
Terpigorev, S.A.; Novikov, A.A.; El-Zein, B.A.; Aleksandrova, E.H.; Iazdovskiĭ, V.V.; Moskalets, O.V.; Paleev, F.N.
Terapevticheskii Arkhiv 85(3): 23-27
2013
ISSN/ISBN: 0040-3660 PMID: 23720838 Document Number: 670881
To assess cytokine spectrum changes in different types of pulmonary sarcoidosis (PS). Twenty-seven PS patients without signs of pulmonary fibrosis and 14 patients with sarcoidosis complicated by pulmonary fibrosis were examined. Baseline serum Th1 and Th2 cytokine concentrations were studied. A control group comprised 30 healthy donors. A higher interleukin (IL)-4/IL-2 ratio was found in the peripheral blood of the patients with pulmonary fibrosis-complicated sarcoidosis than in the other patients (326.4 +/- 122.6 and 88.2 +/- 28.6%, respectively; p = 0.002). The sarcoidosis patients with signs of pulmonary fibrosis and no symptoms of disease inflammatory activity had elevated blood IL-1 levels whereas an IL-1 receptor antagonist was decreased. In the patients with PS, the development and progression of pulmonary fibrosis occur with a shift in the Th1/Th2 balance towards Th2, which manifests itself as a higher IL-4/IL-2 ratio in the peripheral blood. At the same time, the signs of systemic inflammatory activity remain.