Crigler-Najjar type 1 in children
Bach Knudsen, K.; Ebbesen, F.
Ugeskrift for Laeger 175(42): 2489-2491
2013
ISSN/ISBN: 1603-6824 PMID: 24629116 Document Number: 670008
Crigler-Najjar type 1 is a rare congenital disease caused by total lack of activity of bilirubin uridine diphosphate glucuronosyl transferase (UGT1A1) in the liver. The disease is characterised by a persistent severe unconjugated hyperbilirubinaemia. The primary treatment is phototherapy, with oral calcium phosphate as a possible supplementation. The effect of the treatment decreases by age, and if the phototherapy is insufficient the patient will need a liver transplantation. Hepatocyte transplantation has been tried with transient success. The risk of chronic bilirubin encephalopathy is considerable.