Prognostic factors of ulcer colitis flow
Livzan, M.A.; Makeĭkina, M.A.
Eksperimental'naia i Klinicheskaia Gastroenterologiia 8: 17-23
2013
ISSN/ISBN: 1682-8658 PMID: 24933943 Document Number: 669485
The aim of the study was to optimize curation of patients with ulcer colitis based on study of prognostic factors of disease flow. The influence of clinical and instrumental data on the severity of the disease was evaluated in 101 patients with ulcerative colitis (UC) within first 5 years from the disease onset. Blood molecular genetic testing was performed to study the gene polymorphism of IL-12 b A1188C, IL-17 A G-197A, IL-17, F T7488C, TNF-alpha -308 G-308A on the phenotype of the disease. The effect of IL-17 F T7488C, TNF-alpha G-308A gene polymorphisms at the risk of the formation of inflammatory polyps, the prevalence of lesions of the pathological process in the colonic mucosa in the first 5 years disease flow from moderate to severe ulcerative colitis established the prognostic factors of systemic immunosuppressive therapy. However the Influence of IL-12 b A1188C, IL-17 A G-197A gene polymorphisms on the phenotype have been no identified. The contribution of the studied IL-17 F T7488C, TNF-alpha G-308A gene polymorphisms is highly related to the disease phenotype manifestations and peculiar issues associated with therapy volume. Identified prognostic risk factors of systemic immunosuppressant needs allowed us to develop an algorithm of supervision of patients with ulcerative colitis.