Regeneration strategies of intervertebral disc
Fu, W.; Xiang, Z.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 27(2): 227-232
2013
ISSN/ISBN: 1002-1892 PMID: 23596694 Document Number: 669370
To review the research progress of the seed cells, scaffolds, growth factors, and the prospects for clinical application of the intervertebral disc regeneration. The recent literature concerning the regeneration strategies and tissue engineering for treatment of degenerative intervertebral disc disease was extensively reviewed and summarized. Seed cells based on mesenchymal stem cells (MSCs) and multiple-designed biomimetic scaffolds are the hot topic in the field of intervertebral disc regeneration. It needs to be further investigated how to effectively combine the interactions of seed cells, scaffolds, and growth factors and to play their regulation function. The biological regeneration of intervertebral disc would have a very broad prospects for clinical application in future.