Top Abstract Purchase Related
Home
>
Node
>
Subnode

Targeting toll-like receptor signaling as a novel approach to prevent ocular infectious diseases

Pandey, R.K.; Yu, F-Shin.; Kumar, A.

Indian Journal of Medical Research 138(5): 609-619

2013

ISSN/ISBN: 0019-5340
PMID: 24434316
Document Number: 668211
Toll-like receptors (TLRs) play a key role in the innate immune response to invading pathogens. Thus, their discovery has opened up a wide range of therapeutic possibilities for various infectious and inflammatory diseases. In the last several years, extensive research efforts have provided a considerable wealth of information on the expression and function of TLRs in the eye, with significant implications for better understanding of pathogenesis of infectious eye diseases affecting the cornea, uvea, and the retina. In this review, by using bacterial keratitis and endophthalmitis as examples, we discuss the possibilities of targeting TLR signaling for the prevention or treatment of ocular infectious diseases.

Document emailed within 1 workday
Secure & encrypted payments

Schetter, C.; Vollmer, J.ör. 2004: Toll-like receptors involved in the response to microbial pathogens: development of agonists for toll-like receptor 9 Current Opinion in Drug Discovery and Development 7(2): 204-210
Nicoll, A.; Huang, J.; Xie, Z.; Dusan, F.; Le, K.; Gilbert, J.; Gonghuan, Y.; Xiong, W.; Huang, J.; Xie, Z.; Hoile, E.; Nicoll, A.; Smith, A. 2009: Foresight Infectious Diseases China Project--a novel approach to anticipating future trends in risk of infectious diseases in China: methodology and results from an initial application Euro Surveillance: Bulletin Europeen sur les Maladies Transmissibles 14(27)
Kunishima, H.; Kaku, M. 2012: Infectious diseases: progress in diagnosis and treatment. Topics: I. Infectious diseases in unusual circumstances; 1. Infectious diseases post Great East Japan earthquake Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 101(11): 3090-3096
Epler, J.A.; Liu, R.; Chung, H.; Ottoson, N.C.; Shimizu, Y. 2000: Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity Journal of Immunology 165(9): 4941-4949
Glazunov, I.S.; Baubinene, A.V.; Goshtautas, A.A.; Misiavichene, I.S. 1987: Integral approach to the prevention of non-infectious diseases Sovetskaia Meditsina 1987(5): 29-31
Leandro, A.C.C.S.; Rocha, M.A.; Cardoso, C.S.A.; Bonecini-Almeida, M.G. 2009: Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-gamma genes and its association with susceptibility to tuberculosis Brazilian Journal of Medical and Biological Research 42(4): 312-322
Yoshida, S.; Shimada, Y.; Watanabe, H. 2007: Novel approach toward infectious diseases--combating malaria by using genetically engineered mosquitoes Nihon Rinsho. Japanese Journal of Clinical Medicine 65(9): 1715-1726
Takahashi, K.; Kawai, T. 2007: Pathogen recognition by Toll-like receptor Nihon Rinsho. Japanese Journal of Clinical Medicine 65 Suppl 2(Part 1): 53-57
Surmacz, E.; Bartucci, M. 2004: Role of estrogen receptor alpha in modulating IGF-i receptor signaling and function in breast cancer Journal of Experimental and Clinical Cancer Research: Cr 23(3): 385-394
Chalandon, Y.; Schwaller, Jürg. 2005: Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies Haematologica 90(7): 949-968
Nihon-yanagi, Y.; Park, Y.; Ooshiro, M.; Terai, K.; Matsumoto, T.; Murano, T.; Okazumi, S. 2008: Expression of toll-like receptor 4 in colorectal cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 35(12): 2247-2249
Pokrovskiĭ, V.I.; Lobzin, I.V.; Botkin, S.P. 2012: Sergei Petrovich Botkin--the founder of scientific approach to clinical diagnostics of infectious diseases Klinicheskaia Meditsina 90(9): 11-16
Ellert-Zygadłowska, J.; Skibińska-Radzikowska, T.; Tołwińska, I.; Trocha, H. 1979: Typhoid fever and paratyphus in the records of the Department of Infectious Diseases of the Medical Academy and the Provincial Hospital for Infectious Diseases in Gdańsk Polski Tygodnik Lekarski 34(38): 1495-1497
Fouad, N.A.; Saeed, A.M.; Mahedy, A.W. 2019: Toll like Receptor-4 Gene Polymorphism and Susceptibility to Pulmonary Tuberculosis Egyptian Journal of Immunology 26(2): 1-10
Tanir, S.; Karkucak, M.; Yakut, T.; Kilic, S.S. 2010: Toll-like receptor-9 gene polymorphism in common variable immunodeficiency Journal of Investigational Allergology and Clinical Immunology 20(3): 267-268
Mizoguchi, T. 2011: RANKL signaling and bone diseases. Quiescent osteoclast precursors and RANKL signaling Clinical Calcium 21(8): 1187-1192
Boiardi, L.; Casali, B.; Farnetti, E.; Pipitone, N.; Nicoli, D.; Macchioni, P.; Cimino, L.; Bajocchi, G.L.; Catanoso, M.G.; Pattacini, L.; Ghinoi, A.; Restuccia, G.; Salvarani, C. 2009: Toll-like receptor 4 (TLR4) gene polymorphisms in giant cell arteritis Clinical and Experimental Rheumatology 27(1 Suppl 52: S40-S44
Wu, H.-S.; Zhang, J.-X.; Wang, L.; Tian, Y.; Wang, H.; Rotstein, O. 2004: Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice Hepatobiliary and Pancreatic Diseases International: Hbpd Int 3(2): 250-253
Sawa, H.; Ueda, T.; Takeyama, Y.; Yasuda, T.; Shinzeki, M.; Matsumura, N.; Nakajima, T.; Kuroda, Y. 2008: Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis Hepato-Gastroenterology 55(88): 2247-2251
Koval'chuk, L.V.; Khoreva, M.V.; Nikonova, A.S.; Finogenova, N.A.; Mamedova, E.A.; Polovtseva, T.V.; Fetisova, L.I.; Gracheva, L.A.; Goldyreva, N.G. 2010: Toll-like receptor-mediated functional activity of mononuclear cells in children with neutropenia Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 64-68