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Familial Mediterranean fever: a critical digest of the 2012-2013 literature

Eisenstein, E.M.; Berkun, Y.; Ben-Chetrit, E.

Clinical and Experimental Rheumatology 31(3 Suppl. 77): 103-107

2013

ISSN/ISBN: 0392-856X
PMID: 24064023
Document Number: 668185
The year 2012-2013 has been a fertile one in the area of FMF inquiry. Recent studies have led to further insight into the possible mechanisms whereby pyrin mutations might cause the auto-inflammatory phenotype that is characteristic of FMF. Evidence-based guidelines for diagnosis of FMF, including the role of genetic testing, have become available. Risks for colchicine resistance have been partially defined, and a randomised, controlled trial showing efficacy of an interleukin-1 antagonist for treatment of colchicine-resistant or intolerant FMF patients was reported. In this review, we summarise these and other salient findings from the recent FMF literature, and discuss their significance for the clinician.

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