Research progresses of the PARP inhibitors for the treatment of cancer
He, Y.-J.; Liu, R.-H.; Ning, C.-Q.; Yu, N.-F.
Yao Xue Xue Bao 48(5): 655-660
2013
ISSN/ISBN: 0513-4870 PMID: 23888686 Document Number: 667860
The poly(ADP-ribose) polymerases (PARPs) is an important group of enzymes in DNA repair pathways, especially the base excision repair (BER) for DNA single-strand breaks (SSBs) repair. Inhibition of PARP in DNA repair-defective tumors (like those with BRAC1/2 mutations) can lead to cell death and genomic instability, what is so called "synthetic lethality". Currently, PARP inhibitors combined with cytotoxic chemotherapeutic agents in the treatment of BRCA-1/2 deficient cancers are in the clinical development. In this review, we will be focused on the development of combination application of PARP inhibitors with other anticancer agents in clinical trials.