New insight of genome-wide association study (GWAS)
Hotta, K.
Nihon Rinsho. Japanese Journal of Clinical Medicine 71(2): 231-236
2013
ISSN/ISBN: 0047-1852 PMID: 23631198 Document Number: 667287
The number of obese patients is increasing in Japan, due to the westernization of lifestyle. Obesity, especially visceral fat obesity, is important for the development of metabolic syndrome. Genetic factors are important for the development of obesity as well as environmental factors. Importance of genetic factors of fat distribution is also reported. Recent genome-wide association studies (GWASs) have revealed the obesity and fat distribution-related polymorphisms. GWAS will highlight a better understanding of the underlying molecular mechanisms in the regulation of obesity and distribution of body fat.