Amitriptyline versus placebo for major depression
Kessing, L.V.; Bukh, J.D.
Ugeskrift for Laeger 175(34): 1875-1877
2013
ISSN/ISBN: 1603-6824 PMID: 23952981 Document Number: 667172
A recent Cochrane review concluded that amitriptyline is an efficacious antidepressant drug, however associated with a number of side effects. The present paper discusses this finding in relation to studies on effects and side effects of SSRIs and dual-action drugs. It is concluded that there is some evidence for recommending treatment with tricyclic antidepressants (TCA) especially in patients who are hospitalized with severe depression and melancholic features. Further, nortriptylin is preferred due to its more favourable side effects profile.
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