Enantiomers: a new problem in pharmacotherapy of depression?
Grodner, B.ła.; Sitkiewicz, D.
Psychiatria Polska 47(3): 511-518
2013
ISSN/ISBN: 0033-2674 PMID: 23885544 Document Number: 667114
Enantiomers as a optically active forms of drugs now have a big impact on most areas of pharmacotherapy. They arouse a large interest in the field of psychiatry and especially in the treatment of depression. This is due to the fact that enantiomers (chiral forms) of many drugs may have a different pharmacokinetic, pharmacological or pharmacogenetic profiles. Therefore, in many cases the use of a single enantiomer of the drug may have huge advantages over previously used forms and lead to strong improvement of the current treatments. An example is the stereoselective property of such a psychotropic drug fluoxetine as belonging to a group of selective serotonin reuptake inhibitors (SSRI).