Top Abstract Purchase Related
Home
>
Node
>
Subnode

Development of in vitro-in vivo correlation for encapsulated metoprolol tartrate

Khaled, A.A.A.; Pervaiz, K.; Karim, S.; Farzana, K.; Murtaza, G.

Acta Poloniae Pharmaceutica 70(4): 743-747

2013

ISSN/ISBN: 0001-6837
PMID: 23923398
Document Number: 666443
This study was aimed to develop level A, B and C in vitro-in vivo correlation (IVIVC) for encapsulated metoprolol tartrate (T1, T2 and T3 having metoprolol tartrate/polymer ratio of 1: 1, 1: 1.5 and 1: 2,w/w). The in vitro data were correlated with in vivo data. For level A IVIVC, drug absorption data were calculated using Wagner-Nelson method. In addition, convolution approach was used to approximate plasma drug levels from in vitro dissolution data. The coefficient of determination (R2) for level A IVIVC was 0.720, 0.905, 0.928 and 0.878 for Mepressor, T1, T2 andT3 formulations, respectively, with acceptable percent error (< 15%). The value of R2 for level B and C IVIVC was 0.231and 0.714, respectively. It is also concluded that level A IVIVC is a proficient mathematical model for biowaiver studies involving study parameters as those implemented for T1S (T1formulation tested for dissolution in the presence of sodium lauryl sulfate) revealing that IVIVC level A is dosage form specific, rather than to be drug specific.

Document emailed within 1 workday
Secure & encrypted payments

Ijaz, H.; Qureshi, J.; Danish, Z.; Zaman, M.; Abdel-Daim, M.; Hanif, M.; Waheed, I.; Mohammad, I.S. 2015: Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate Pakistan Journal of Pharmaceutical Sciences 28(6): 2019-2025
Solov'ev, O.V.; Efremov, D.N.; Onuchina, E.L.; Solov'eva, N.V.; Kononov, S.V. 2009: The use of metoprolol tartrate during restoration of sinus rhythm and its subsequent maintenance in patients with chronic atrial fibrillation Kardiologiia 49(5): 26-29
Guo, H.Y.; Colangelo, D.; Li, L.; Connors, K.M.; Kubota, T.; Hoffman, R.M. 1992: In vitro histoculture of human tumors with fluorescent dye end-points measured by confocal microscopy: high correlation of in vitro and in vivo chemosensitivity Anticancer Research 12(4): 1055-1061
Vogel, C.N.; Kingdon, H.S.; Lundblad, R.L. 1979: Correlation of in vivo and in vitro inhibition of thrombin by plasma inhibitors Journal of Laboratory and Clinical Medicine 93(4): 661-673
Golub, S.H.; O'Connell, T.X.; Morton, D.L. 1974: Correlation of in vivo and in vitro assays of immunocompetence in cancer patients Cancer Research 34(8): 1833-1837
Babalola, C.P.; Oladimeji, F.A.; Femi-Oyewo, M.N. 2001: Correlation between in vitro and in vivo parameters of commercial paracetamol tablets African Journal of Medicine and Medical Sciences 30(4): 275-280
El-Khordagui, L.K.; Saleh, A.M.; KhalIl, S.A. 1987: Adsorption of benzodiazepines on charcoal and its correlation with in vitro and in vivo data Pharmaceutica Acta Helvetiae 62(1): 28-32
Rose, W.C.; Schurig, J.E.; Meeker, J.B. 1988: Correlation of in vitro cytotoxicity with preclinical in vivo antitumor activity Anticancer Research 8(3): 355-367
Hecker, D.; Rose, H.; Powitz, A. 1978: The correlation of in vivo and in vitro effect of cytostatics in transplantated tumours of the mouse Acta Histochemica 62(1): 95-109
Al-Tawil, N.G.; Berggren, G.; Emtestam, L.; Fransson, J.; Jernselius, R.; Marcusson, J.A. 1985: Correlation between quantitative in vivo and in vitro responses in nickel-allergic patients Acta Dermato-Venereologica 65(5): 385-389
Ebbesen, P.; Olsson, L.; Rudkobing, O.; Haahr, S.; Kristensen, G. 1977: Correlation of in vivo cancer, net outer charge, in vitro migration, interferon activity, in vitro growth rates, and chalone-like activity to transformation-reversion in cloned Moloney and Kristen sarcoma virus-transformed mouse 3T3 cells Cancer Research 37(12): 4285-4290
Al-Meshal, M.A. 1990: In-vitro and in-vivo correlation of enhancement of dissolution rate of water insoluble drugs Research Communications in Chemical Pathology and Pharmacology 67(3): 415-418
Nara, P.L.; Krakowka, S.; Powers, T.E.; Garg, R.C. 1983: Experimental Streptococcus equi infection in the horse: correlation with in vivo and in vitro immune responses American Journal of Veterinary Research 44(4): 529-534
Gierthy, J.F.; Bennett, J.A.; Bradley, L.M.; Cutler, D.S. 1993: Correlation of in vitro and in vivo growth suppression of MCF-7 human breast cancer by 2,3,7,8-tetrachlorodibenzo-p-dioxin Cancer Research 53(13): 3149-3153
Brockmeier, D.; Voegele, D.; von Hattingberg, H.M. 1983: In vitro--in vivo correlation, a time scaling problem? Basic techniques for testing equivalence Arzneimittel-Forschung 33(4): 598-601
Dutartre, P.; Annat, J.; Derrepas, P.; Guerrin, F.; Reboul, A.; Tripier, M. 1992: IMOCUR stimulates production of immunoglobulins; preliminary results concerning a correlation between in vitro and in vivo experiments Developments in Biological Standardization 77: 57-64
Gupta, V.; Krishan, A.; Zubrod, C.G. 1983: Correlation of in vitro clonogenic assay data with in vivo growth delays and cell cycle changes of a human melanoma xenograft Cancer Research 43(6): 2560-2564
Nicolau, C.; Le Pape, A.; Soriano, P.; Fargette, F.; Muh, J.P.; Juhel, M.F. 1982: In vivo transfer and expression of the liposome encapsulated rat insulin gene Progress in Clinical and Biological Research 102 Pt A: 321-330
Tropé, C.; Sigurdsson, K. 1982: Use of tissue culture in predictive testing of drug sensitivity in human ovarian cancer. Correlation between in vitro results and the response in vivo Neoplasma 29(3): 309-314
Regazzi, M.B.; Rondanelli, R.; Calvi, M.; Brè, E.; Restelli, E. 1985: In vivo disposibility of caffeine and ergotamine tartrate after rectal administration Il Farmaco; Edizione Pratica 40(8): 259-265