Evaluation of an antimicrobial silver foam dressing
Park, J.K.; Lee, J.H.; Kwak, J.J.; Shin, H.B.; Jung, H.W.; Bae, S.W.; Yeo, E.D.; Lee, Y.K.; Yang, S.S.
Wounds a Compendium of Clinical Research and Practice 25(6): 153-159
2013
ISSN/ISBN: 1943-2704 PMID: 25866981 Document Number: 666315
CuraVAC Ag, a product that delivers negative pressure wound therapy through a polyurethane foam dressing, contains silver nanoparticles, which, when moistened with water, release silver ions onto a wound surface. The in vitro antimicrobial action of silver can destroy both gram-positive and gram-negative bacteria, as well as methicillin-resistant Staphylococcus aureus (MRSA). The purpose of this study was to assess the efficacy and in vivo outcomes of using the product. Thirty-six female Sprague-Dawley white rats, 8-weeks old and 250 g - 300 g in weight, were used. The experimental product was prepared using a vacuum-assisted closure (VAC) kit and coating it using the silver nanoparticles. For the control group, a 10% povidone-iodine solution was applied. All groups showed decreases in wound area over time, in the order CuraVAC Ag (group A) > CuraVAC (group B) > control (group C). On the third, fifth, and seventh days, wound healing efficacy scores increased in both group A and group C. Groups A and B showed more rapid decreases than group C in bacterial culture from wounds. CuraVAC Ag may be useful for treatment of wounds infected with bacteria..