Regulation of bone metabolisms by estrogen/estrogen receptors signaling
Imai, Y.
Clinical Calcium 23(11): 1621-1626
2013
ISSN/ISBN: 0917-5857 PMID: 24162602 Document Number: 665002
Postmenopausal osteoporosis is caused by estrogen deficiency. The precise mechanism was unclear how estrogen maintains bone mass and how estrogen deficiency alters bone metabolism. However, the progress of generation and analyses of estrogen receptorα (ERα) conditional knockout mice have revealed the pathophysiology of postmenopausal osteoporosis. Here we introduce recent reports related to the estrogen/ERα mediated direct and indirect regulations in bone metabolism.
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