Autonomous pharmacodynamics of organic nitrates in patients with unstable angina
Safronova, É A.; Mironova, T.F.; Shadrina, I.M.
Klinicheskaia Meditsina 91(7): 32-38
2013
ISSN/ISBN: 0023-2149 PMID: 24437167 Document Number: 664624
The pharmacological test with the use of high-resolution rhythmocardiography for the analysis of cardiac rhythm variability associated with peripheral vegetative regulation of the synoatrial node was applied to study effects of a single dose of organic nitrates (nitroglycerin and mononitrate isosorbide) in 41 patients with unstable angina. Rhythmocardiograms were obtained before and after a morning sublingual dose of nitrates preceding intake of basal drugs. The results suggest negative action of nitrates on peripheral vegetative regulation of pacemaker activity of the synoatrial node.