Refractory celiac disease
Iwańczak, F.; Iwańczak, B.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 35(205): 47-50
2013
ISSN/ISBN: 1426-9686 PMID: 23984606 Document Number: 664236
Refractory celiac disease is characterized by the persistence or recurrence of symptoms connected with enteropathy, presence of specific antibodies in the serum: EMA, tTG2 and DPG, and (or) intestinal villous atrophy despite strict adherence to gluten-free diet for 6 to 12 months. Correct initial diagnosis of celiac disease, exclusion of other causes of the lack of response to gluten-free diet and persistence of villous atrophy are necessary conditions of diagnosis of refractory celiac disease. Options of the treatment, depending on the patient condition are: gluten-free diet, elementary diet, parenteral nutrition, immunosuppression and biological therapy.