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Interleukin-6 in endemic goiter patients in the south Ural region

Popova, E.V.; Popova, N.P.; Aliab'eva, I.V.; Gatiatulina, E.R.

Gigiena i Sanitariia 3: 9-10

2012

ISSN/ISBN: 0016-9900
PMID: 23088108
Document Number: 663669
The cytokine and thyroid status was studied in patients with endemic goiter (EG) depending on thyroid function. IL-6 correlated with free T3 levels (a negative relationship) in hyperthyroidism, with IL-2 and IFN-gamma levels in EG patients with euthyroidism, and with IL-1beta, IL-2, IL-8, IL-10, and IFN-gamma in hypothyroidism. The EG patients with high IL-6 levels showed positive relationships to IL-2 and thyroid peroxidase antibodies and a negative relationship to free T3. In these patients, IL-6 acted to stimulate the secretion of antithyroid antibodies, which is a risk of autoimmune thyroiditis.

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