Evaluation of anti convulsant activity of aerial parts of Phyllanthus longiflorus heyne ex hook
Jesupillai, M.; Thillai Arasu, P.; Jasemine, S.; Bharathidhasan, P.
European Review for Medical and Pharmacological Sciences 16(Suppl 3): 28-30
2012
ISSN/ISBN: 1128-3602 PMID: 22957415 Document Number: 663266
To evaluate anti convulsant effect of aerial parts of Phyllanthus longiflorus (PHL). Methanol extract of aerial parts of PHL (MPHL) was prepared by continuous hot extraction method using Soxhlet apparatus. MPHL at the doses 100, 200 and 400 mg/kg were administered to male albino mice by oral route and the activity was assessed against maximal electro shock (MES) and pentylene tetrazole (PTZ) induced seizure. Abolition of hind limb extension and onset of clonic convulsion were taken as a measure of MES and PTZ induced convulsion respectively. MPHL reduced the duration of extensor phase of convulsion in MES test by 62.5% (at 400 mg/kg) and also delayed the onset of clonic phase of convulsion in PTZ test by 50.7% (at 400 mg/kg). The activity was significant (p < 0.01) and comparable to the reference drug diazepam (2 mg/kg). Results suggest that aerial parts of Phyllanthus longiflorus are useful in the management of convulsion.