Establishment of skin scald model in mice
Ren, P.; Guan, D.-W.; Zhao, R.; Ma, W.-X.; Zhang, S.-T.
Fa Yi Xue Za Zhi 28(2): 92
2012
ISSN/ISBN: 1004-5619 PMID: 22619801 Document Number: 662978
To establish the model of skin scald in mice for the study of skin thermal injuries. After anaesthetization mice were scalded in a 1 cm-diameter circle area on the central dorsum by boiling water at contact times: 10s or 25s. The mice were sacrificed at 1, 3, 5, 7 and 10 days after scald. The skin samples were collected and analyzed by gross and histopathological examinations. Deep II degree thermal injury involving full-thickness skin was observed in the 10s scald group. III degree thermal injury involving full-thickness skin and the dorsal skeletal muscle was observed in the 25 s scald group. A mouse skin scald model is established which is stable and can be used on the skin thermal injury in future research.